The National Shrine Grotto of Lourdes is located just south of Emmitsburg, MD, off of US Route 15

From Baltimore
I-695 exit 20 to I-795 to MD 140. Follow MD 140 through Westminster and Taneytown to Emmitsburg. Follow the signs to US 15 south and travel approximately 3 miles; pass Mount St. Mary's University and look for signs (Grotto turn off will be on the right). After leaving US 15, turn left at the stop sign onto St. Anthony Rd. Turn right onto Grotto Rd.

From Washington, DC, and Frederick, MD
Take I-270 north to US 15, past Frederick and north towards Emmitsburg. Approximately 6 miles north of Thurmont look for signs. You will make a left turn just before arriving at Mount St. Mary's University. After leaving US 15, turn left at the stop sign onto St. Anthony Rd. Turn right onto Grotto Rd.

From Harrisburg, PA
Travel south on US 15 past the Emmitsburg exits. Follow US 15 south just beyond Mount St. Mary's University. Look for signs (Grotto turn off will be on the right). After leaving US 15, turn left at the stop sign onto St. Anthony Rd. Turn right onto Grotto Rd.